Letter | Published:

Permeability of the Synovial Membrane to Glycoproteins

Naturevolume 192page1192 (1961) | Download Citation



ELECTROPHORETIC investigations have indicated differences in glycoprotein pattern between serum and synovial fluid1–3. The most marked difference is that the relative amount of α2-glycoproteins is considerably less in synovial fluid than in serum. It was recently demonstrated4 that the low α2-content of rheumatoid arthritic synovial fluid is mainly due to the low concentration of haptoglobin. The synovial fluid–serum ratio for this glycoprotein was significantly lower than for albumin or γ-globulin. The concentration of the small-molecular glycoprotein orosomucoid was, on the other hand, that expected from the total protein content, indicating a varied permeability of the blood-synovial fluid barrier to glycoproteins.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Sandson, J., and Hamerman, D., Proc. Soc. Exp. Med., 98, 564 (1958).

  2. 2

    Decker, B., McKenzie, B. F., McGuckin, W. F., and Slocumb, Ch. H., Arthritis Rheumat., 2, 162 (1959).

  3. 3

    Nettelbladt, E., and Sundblad, L., Arthritis Rheumat., 2, 144 (1959).

  4. 4

    Nettelbladt, E., and Sundblad, L., Arthritis Rheumat., 4, 161 (1961).

  5. 5

    Cho, M. H., and Neuhaus, O. W., Tromb. et Diath. Haemorrhag., 5, 108 (1960).

  6. 6

    Sundblad, L., and Wallin-Nilsson, M., Opuscula Med., 8, 271 (1960).

  7. 7

    Sundblad, L., and Wallin-Nilsson, M., Scand. J. Clin. Lab. Invest. (in the press).

  8. 8

    Owren, P., and Aas, K., Scand. J. Clin. Lab. Invest., 3, 201 (1951).

Download references

Author information


  1. Central Clinical Laboratory and Medical Department III, Södersjukhuset (South Hospital), Stockholm



  1. Search for LARS SUNDBLAD in:

  2. Search for ERIC JONSSON in:

  3. Search for ERIK NETTELBLADT in:

About this article

Publication history

Issue Date




By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.