Abstract
ELECTROPHORETIC investigations have indicated differences in glycoprotein pattern between serum and synovial fluid1–3. The most marked difference is that the relative amount of α2-glycoproteins is considerably less in synovial fluid than in serum. It was recently demonstrated4 that the low α2-content of rheumatoid arthritic synovial fluid is mainly due to the low concentration of haptoglobin. The synovial fluid–serum ratio for this glycoprotein was significantly lower than for albumin or γ-globulin. The concentration of the small-molecular glycoprotein orosomucoid was, on the other hand, that expected from the total protein content, indicating a varied permeability of the blood-synovial fluid barrier to glycoproteins.
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SUNDBLAD, L., JONSSON, E. & NETTELBLADT, E. Permeability of the Synovial Membrane to Glycoproteins. Nature 192, 1192 (1961). https://doi.org/10.1038/1921192a0
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DOI: https://doi.org/10.1038/1921192a0
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