IN 1948, Korkes and Ochoa1 described an enzyme preparation from Lactobacillus arabinosus which catalysed the conversion of L-malic acid to lactic acid and carbon dioxide. They called it malic enzyme. The activity of this enzyme was found to be very low in organisms grown on ordinary medium. When malic acid was also included in the medium during growth, the ability of the organisms to break down malic acid was found to have increased about fifty times. They also demonstrated that the presence of the growth medium and glucose was essential to the formation of the enzyme.
Korkes, S., and Ochoa, S., J. Biol. Chem., 176, 463 (1948).
Snell, E. E., J. Bact., 50, 373 (1945).
Gale, E. F., Biochem. J., 34, 392 (1940).
Lichstein, H. C., Ann. Rev. Microbiol., 14, 17 (1960).
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BOCKS, S. Nutritional Requirements for the Induced Formation of Malic Enzyme in Lactobacillus arabinosus (17–5). Nature 192, 89–90 (1961). https://doi.org/10.1038/192089a0
Archiv f�r Mikrobiologie (1969)