Specificity of the Mutagenic Action of the Alkylating Agents


ETHYL methanesulphonate is mutagenic when applied to mature bacteriophage particles in suspension1. Methyl methanesuiphonate is either non- mutagenic or results in the induction of mutants at a frequency not much greater than the spontaneous frequency2. Krieg (quoted by Bautz and Freese2) has reported that ethyl methanesuiphon te will not induce reversion of bacteriophage mutations induced by itself. Mutants induced by ethyl methane- suiphonate can be induced to revert with 2-aminopurine2. Methyl methanesuiphonate is much more lethal on a molar basis than is the ethyl derivative1.

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    Loveless, A., Proc. Roy. Soc., B, 150, 497 (1959).

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    Bautz, E., and Freese, E., Proc. U.S. Nat. Acad. Sci., 46, 1585 (1960).

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    Alper, T., and Gillies, N., J. Gen. Microbiol., 22, 113 (1960).

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    Loveless, A., and Stock, J. C., Proc. Roy. Soc., B, 151, 129 (1959). Strauss, B., J. Bacteriol., 81, 573 (1961).

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STRAUSS, B. Specificity of the Mutagenic Action of the Alkylating Agents. Nature 191, 730–731 (1961). https://doi.org/10.1038/191730a0

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