Abstract
SEVERAL coumarin and indanedione drugs are capable of inducing hypoprothrombinæmia, presumably by interfering with the cofactor role of vitamin K in prothrombin synthesis. This role of vitamin K, probably involving electron transport, can be competitively inhibited by coumarins, and the inhibition competitively overcome by large doses of vitamin K (ref. 1).
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References
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WEINER, M., CHENKIN, T. & DAYTON, P. Lack of Effect of Coenzyme Q10 on Coumarin-induced Hypoprothrombinæmia. Nature 191, 711 (1961). https://doi.org/10.1038/191711a0
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DOI: https://doi.org/10.1038/191711a0
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