Lack of Effect of Coenzyme Q10 on Coumarin-induced Hypoprothrombinæmia


SEVERAL coumarin and indanedione drugs are capable of inducing hypoprothrombinæmia, presumably by interfering with the cofactor role of vitamin K in prothrombin synthesis. This role of vitamin K, probably involving electron transport, can be competitively inhibited by coumarins, and the inhibition competitively overcome by large doses of vitamin K (ref. 1).

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    Link, K. P., Harvey Lectures, 39, 162 (1944).

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    Green, D. M., and Lester, R. L., Fed. Proc., 18, 987 (1959).

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    Sastry, P. S., Jayaraman, J., and Ramasarma, T., Nature, 189, 577 (1961).

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    Chenkin, T., Dayton, P. G., Weisberg, L. G., and Weiner, M., Exp. Med. and Surg., 17, 219 (1960).

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WEINER, M., CHENKIN, T. & DAYTON, P. Lack of Effect of Coenzyme Q10 on Coumarin-induced Hypoprothrombinæmia. Nature 191, 711 (1961).

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