Localization of the ‘Sugar Pump’ in the Intestinal Epithelium


GLUCOSE is actively transported across the intestinal epithelium from the lumen of the gut into the blood in vivo or into the fluid surrounding the serosal mesothelium in vitro. Because part of the glucose is metabolized during transport, it is not possible to determine the concentration of the unaltered sugar in the various layers of the intestine. However, 3-O-methylglucose, though transported by the same mechanism which acts on glucose1, is not metabolized in animal tissue2,3. The synthesis of 3-O-14CH3-glucose in this laboratory3 offered a method of following with reasonable accuracy the route of this sugar during transport.

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    Csáky, T. Z., Supp. Int. Abstracts Biol. Sci., 6 (1958).

  2. 2

    Csáky, T. Z., and Glenn, J. E., Amer. J. Biol., 188, 159 (1957).

  3. 3

    Csáky, T. Z., and Wilson, J. E., Biochim. Biophys. Acta, 22, 185 (1956).

  4. 4

    Csáky, T. Z., and Fernald, G. W., Amer. J. Physiol., 198, 445 (1960).

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CSÁKY, T., FERNALD, G. Localization of the ‘Sugar Pump’ in the Intestinal Epithelium. Nature 191, 709–710 (1961). https://doi.org/10.1038/191709a0

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