Sub-unit of Ribosomal Ribonucleic Acid from Yeast


RIBONUCLEIC acid (RNA) isolated by the phenol method from 80s ribosomes of yeast was demonstrated to contain two components of 19s and 28s 1. In a previous paper2, it was shown that by heat treatment the high molecular ribosomal RNA could easily be converted to a low molecular RNA with the sedimentation coefficient of about 4s. It is also the case for rat liver ribosomal RNA as demonstrated by Takanami3. The close agreement of the s-value of this heat-treated ribosomal RNA with that of soluble RNA led us to suppose that the 4s polynucleotide is the basic unit of all RNA's2. In the present work, it has been shown that trypsin, as in the case of heat treatment, can degrade ribosomal RNA into 4s sub-units.

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  1. 1

    Maeda, A., J. Biochem. (Tokyo), 48, 363 (1960).

  2. 2

    Osawa, S., Biochim. Biophys. Acta, 43, 111 (1960).

  3. 3

    Takanami, M., Biochim. Biophys. Acta, 39, 152 (1960).

  4. 4

    Brown, R. A., Ellem, K. A. O., and Colter, J. S., Nature, 187, 509 (1960).

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OTAKA, E., OOTA, Y. & OSAWA, S. Sub-unit of Ribosomal Ribonucleic Acid from Yeast. Nature 191, 598–599 (1961).

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