Letter | Published:

Action of Influenza Viruses, Receptor-destroying Enzyme and Proteases on Blood Group Agglutinogen M g

Naturevolume 191pages187188 (1961) | Download Citation



THE ability of influenza viruses and receptor-destroying enzyme from Vibrio cholerae to inactivate human erythrocyte agglutinogens M and N was first noted in this Laboratory1 and afterwards independently in Finland2. Lu a and Lu b agglutinogens are also inactivated by influenza viruses but not by the receptor-destroying enzyme3. None of 17 additional human blood group agglutinogens—including S and s which are considered to be products of genes very closely linked to the M and N genes—was destroyed by these agents1,3. On the other hand, the inactivation of a number of erythrocyte agglutinogens including M and N by papain, trypsin and other enzymes has been known for a considerable time4–6.

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    Springer, G. F., and Ansell, N. J., Proc. U.S. Nat. Acad. Sci., 44, 182 (1958).

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    Springer, G. F., and Ansell, N. J., Proc. Seventh Congr. Intern. Soc. Blood Transf., 697 (S. Karger, Basle and New York, 1959).

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    Gottschalk, G. F., The Chemistry and Biology of Sialic Acids, 99 (Cambridge University Press, 1960).

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    Baranowski, T., Lisowska, E., Morawiecki, A., Romanowska, E., Strozecka, K., Arch. Immunol. terap. Doswiad., 7, 15 (1959).

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  1. GEORG F. SPRINGER: Established Investigator of the American Heart Association.

  2. KARLHEINZ STALDER: On leave from the Max Planck Society, Göttingen.


  1. Immunochemistry Section, William Pepper Laboratory and Department of Medical Microbiology, University of Pennsylvania, Philadelphia



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