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Changes in Blood Serotonin during Exposure to Cold

Naturevolume 191pages183184 (1961) | Download Citation



SEROTONIN is a recently discovered biogenic amine which can be extracted from brain, blood, and other organs, and which is active on a wide variety of systems when injected into the animal1. Gathering of knowledge concerning serotonin's physiological importance has been slowed by an inability to observe fluctuations in its concentration in brain and other tissues, in a wide variety of circumstances simulating physiological mobilization2–4. A single exception to this is the observation of a release of serotonin into the bowel, controlled by, and in turn modifying, peristaltic activity5. Also, more recently, Toh has reported rat brain serotonin to drop following exposure to cold associated with drop in body-temperature of 36–30° C. (ref. 3).

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    Erspamer, V., Pharm. Rev., 6, 425 (1954).

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    Towne, J. C., and Sherman, J. O., Proc. Soc. Exp. Biol. Med., 103, 721 (1960).

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    Toh, C. C., J. Physiol., 151, 410 (1960).

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    Towne, J. C. (personal communication).

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    Present address: Department of Pharmacology, The Chicago Medical School, Chicago, Illinois


  1. Department of Pharmacology, Northwestern University, Medical School, Chicago, Illinois



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