Letter | Published:

Changes in Blood Serotonin during Exposure to Cold

Naturevolume 191pages183184 (1961) | Download Citation

Subjects

Abstract

SEROTONIN is a recently discovered biogenic amine which can be extracted from brain, blood, and other organs, and which is active on a wide variety of systems when injected into the animal1. Gathering of knowledge concerning serotonin's physiological importance has been slowed by an inability to observe fluctuations in its concentration in brain and other tissues, in a wide variety of circumstances simulating physiological mobilization2–4. A single exception to this is the observation of a release of serotonin into the bowel, controlled by, and in turn modifying, peristaltic activity5. Also, more recently, Toh has reported rat brain serotonin to drop following exposure to cold associated with drop in body-temperature of 36–30° C. (ref. 3).

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Erspamer, V., Pharm. Rev., 6, 425 (1954).

  2. 2

    Towne, J. C., and Sherman, J. O., Proc. Soc. Exp. Biol. Med., 103, 721 (1960).

  3. 3

    Toh, C. C., J. Physiol., 151, 410 (1960).

  4. 4

    Towne, J. C. (personal communication).

  5. 5

    Lee, C. Y., J. Physiol., 152, 405 (1960).

  6. 6

    Weissbach, H., Waalkes, T. P., and Udenfriend, S., J. Biol. Chem., 230, 865 (1958).

  7. 7

    Bogdanski, D. F., Pletscher, A., Brodie, B. B., and Udenfriend, S., J. Pharm. Exp. Ther., 117, 82 (1956).

  8. 8

    Erspamer, V., J. Physiol., 133, 1 (1956).

  9. 9

    Humphrey, J. H., and Jaques, R., J. Physiol., 124, 305 (1954).

  10. 10

    Udenfriend, S., and Weissbach, H., Fed. Proc., 13, 412 (1954).

  11. 11

    Erspamer, V., and Faustini, R., Naturwiss., 40, 317 (1953).

Download references

Author information

Author notes

    • PAUL GORDON

    Present address: Department of Pharmacology, The Chicago Medical School, Chicago, Illinois

Affiliations

  1. Department of Pharmacology, Northwestern University, Medical School, Chicago, Illinois

    • PAUL GORDON

Authors

  1. Search for PAUL GORDON in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/191183b0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.