Changes in Blood Serotonin during Exposure to Cold

Abstract

SEROTONIN is a recently discovered biogenic amine which can be extracted from brain, blood, and other organs, and which is active on a wide variety of systems when injected into the animal1. Gathering of knowledge concerning serotonin's physiological importance has been slowed by an inability to observe fluctuations in its concentration in brain and other tissues, in a wide variety of circumstances simulating physiological mobilization2–4. A single exception to this is the observation of a release of serotonin into the bowel, controlled by, and in turn modifying, peristaltic activity5. Also, more recently, Toh has reported rat brain serotonin to drop following exposure to cold associated with drop in body-temperature of 36–30° C. (ref. 3).

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Erspamer, V., Pharm. Rev., 6, 425 (1954).

    CAS  PubMed  Google Scholar 

  2. 2

    Towne, J. C., and Sherman, J. O., Proc. Soc. Exp. Biol. Med., 103, 721 (1960).

    CAS  Article  Google Scholar 

  3. 3

    Toh, C. C., J. Physiol., 151, 410 (1960).

    CAS  Article  Google Scholar 

  4. 4

    Towne, J. C. (personal communication).

  5. 5

    Lee, C. Y., J. Physiol., 152, 405 (1960).

    CAS  Article  Google Scholar 

  6. 6

    Weissbach, H., Waalkes, T. P., and Udenfriend, S., J. Biol. Chem., 230, 865 (1958).

    CAS  Google Scholar 

  7. 7

    Bogdanski, D. F., Pletscher, A., Brodie, B. B., and Udenfriend, S., J. Pharm. Exp. Ther., 117, 82 (1956).

    CAS  Google Scholar 

  8. 8

    Erspamer, V., J. Physiol., 133, 1 (1956).

    CAS  Article  Google Scholar 

  9. 9

    Humphrey, J. H., and Jaques, R., J. Physiol., 124, 305 (1954).

    CAS  Article  Google Scholar 

  10. 10

    Udenfriend, S., and Weissbach, H., Fed. Proc., 13, 412 (1954).

    Google Scholar 

  11. 11

    Erspamer, V., and Faustini, R., Naturwiss., 40, 317 (1953).

    ADS  CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

GORDON, P. Changes in Blood Serotonin during Exposure to Cold. Nature 191, 183–184 (1961). https://doi.org/10.1038/191183b0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.