Function of the Fœtal Thyroid of the Rabbit with regard to Cholesterol Metabolism studied by Fœtal Thyroidectomy

Abstract

IN earlier communications, it was reported that the fœtal pituitary–thyroid system influenced cholesterol and fat metabolism. Following removal of this system, a significant rise in the serum cholesterol occurred1, and also in the fat content of the fœtal liver2. The technique for removing the fœtal pituitary and thyroid involves decapitation of the fœtus either through the neck to remove both the thyroid as well as the pituitary, or through the mouth to preserve the thyroid. It has already been ehown that this operation has no significant effect on the weight development of the fœtus2–4, but it may be objected that the metabolic changes may be the result of removing structures other than the pituitary and the thyroid, such as the brain.

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References

  1. 1

    Bearn, J. G., Koerselman, H. B., and Pilkington, T. R. E., Nature, 189, 318 (1961).

  2. 2

    Bearn, J. G., Nature, 185, 849 (1960).

  3. 3

    Jost, A., Cold Spring Harbor Symposia Quant. Biol., 19, 167 (1954).

  4. 4

    Bearn, J. G., C.R. Acad. Sci., Paris, 250, 198 (1960).

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BEARN, J., KOERSELMAN, H. & PILKINGTON, T. Function of the Fœtal Thyroid of the Rabbit with regard to Cholesterol Metabolism studied by Fœtal Thyroidectomy. Nature 190, 822–823 (1961). https://doi.org/10.1038/190822b0

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