Abstract
WHILE making a topographical survey of the distribution of cholinesterases in the spinal cord and brain stem of the chicken in relation to the question of the selective neurotoxicity of certain organophosphorus compounds, we were led to make a comparison in four laboratory mammals (to be published). Koelle1 had shown histochemically in the rat that considerable variation exists in the cholinesterase content of neurones from one centre to another. Hebb2 also recognized in mammals neurones where the cholinesterase was for the most part intracellular (cholinergic) and neurones where it was largely distributed on the neuronal membrane (cholinoceptive). In contrast to this variability in mammals, the distribution of cholinesterase in chicken neurones is strikingly uniform.
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References
Koelle, G. B., J. Comp. Neurol., 100, 211 (1954).
Hebb, C., Acta Physiol. Pharmacol. Neerland., 6, 121 (1957); Nature, 180, 627 (1957).
Giacobini, E., Acta Physiol. Scand., 45, 238 (1959).
Hebb, C., Physiol. Rev., 37, 196 (1957).
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CAVANAGH, J., HOLLAND, P. Cholinesterase in the Chicken Nervous System. Nature 190, 735–736 (1961). https://doi.org/10.1038/190735a0
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DOI: https://doi.org/10.1038/190735a0
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