A Heteroglycan from Toxoplasma gondii


LITTLE is known about the biochemical determinants of virulence and antigenicity in Protozoa. So far as we are aware, no immunochemical studies on Toxoplasma gondii have yet been reported, except the work of Hook and Faber1. They showed that cytoplasm-modifying and complement-fixing antibodies were related to the protein, but not carbohydrate fractions, obtained from sonically fragmented cells. Lunde and Jacobs2 concluded that the Toxoplasma hæmagglutination test antigen was a protein contained in the crude lysate of washed parasites; but no attempts were made to isolate and identify the soluble antigens in a relatively pure state.

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  1. 1

    Hook, W. A., and Faber, J. E., Exp. Parasit., 6, 449 (1957).

  2. 2

    Lunde, M. N., and Jacobs, L., J. Immunol., 82, 146 (1959).

  3. 3

    Fulton, J. D., and Spooner, D. F., Trans. Roy. Soc. Trop. Med. Hyg., 51, 123 (1957).

  4. 4

    Pande, P. G., Shukla, R. R., and Sekariah, P. C., Curr. Sci. (in the press).

  5. 5

    Rowley, D., Brit. J. Exp. Path., 37, 223 (1956).

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PANDE, P., SHUKLA, R. & SEKARIAH, P. A Heteroglycan from Toxoplasma gondii . Nature 190, 644–645 (1961). https://doi.org/10.1038/190644a0

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