Introduction of the 16α-Hydroxyl Group into Œstrogens by Streptomycetes


PAPERS concerned with the microbiological transformation of steroids have appeared frequently in the past seven years; however, no examples of the hydroxylation of steroids with a benzenoid A ring have been observed. We have been able to introduce a hydroxyl group into the 16α-position of œstrone and œstradiol with two strains of Streptomyces halstedii (ATCC 13,499 and NRRL B-2138) and Streptomyces mediocidicus ATCC 13,278.

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KITA, D., SARDINAS, J. & SHULL, G. Introduction of the 16α-Hydroxyl Group into Œstrogens by Streptomycetes. Nature 190, 627–628 (1961).

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