Circulating Platelets in Mice subjected to Simultaneous X-ray and Ultra-violet Irradiation

Abstract

THE circulating platelet count of mice increases significantly after ultra-violet irradiation. Five to seven days after a single whole-body ultra-violet irradiation the increase is about 100 per cent. Para-biosis experiments, as well as the positive effect of isologous serum transfer, suggested that humoral factor(s) are responsible for the thrombocytopoietic effect and the agent seemed to be a protein-like macromolecule1 as already described for human serum2. In the present experiments we investigated the simultaneous action of whole-body X-ray irradiation, that is, a procedure causing severe thrombocytopenia, and ultra-violet radiation, that is, a procedure causing marked thrombocytosis.

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References

  1. 1

    Cserháti, I., and Rák, K., Z. ges. exp. Med., 138, 38 (1958).

  2. 2

    Rák, K., Cserháti, I., and Kelemen, E., Medicina Experimentalis, 1, 125 (1959).

  3. 3

    Feissly, R., and Lüdin, H., Rev. Hématol., 4, 481 (1949).

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CSERHÁTI, I., KRIZSA, F. & RÁK, K. Circulating Platelets in Mice subjected to Simultaneous X-ray and Ultra-violet Irradiation. Nature 190, 544–545 (1961). https://doi.org/10.1038/190544b0

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