Experimental Oxidation of Hæmoglobin: its Relation to Growth-rate in Rats

Abstract

THE sensitivity of oxyhæmoglobin to oxidation with nitrites or ferricyanide is increased in children, pregnant women and patients with carcinomata (refs. 1–4 and preceding communication). The change-over from the increased sensitivity of childhood to the adult reaction occurs at about the age of puberty. To investigate the relationship between this reaction and the hormonal changes of puberty, the phenomenon has been studied in rats, as the growth-rate and pubertal changes can be determined and separated much more readily in small mammals than in man.

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References

  1. 1

    Keohane, K. W., and Metcalf, W. K., Phys. in Med. and Biol., 5, 27 (1960).

  2. 2

    Keohane, K. W., and Metcalf, W. K., J. Anat., 94, 454 (P) (1960).

  3. 3

    Metcalf, W. K., Proc. Anat. Soc. (July, 1960).

  4. 4

    Metcalf, W. K., Phys. in Med. and Biol., 5, 259 (1961).

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METCALF, W. Experimental Oxidation of Hæmoglobin: its Relation to Growth-rate in Rats. Nature 190, 543–544 (1961). https://doi.org/10.1038/190543b0

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