Abstract
UNTIL recent years, methanol and ethanol were universally regarded only as precipitants for nucleic acids. However, Geiduschek and Holtzer1, and later Coates and Jordan2, showed that at sufficiently low ionic strengths both the above lose their precipitating capacity for deoxyribonucleic acid (DNA) and in fact becomes fairly good solvents, depending upon the concentration of electrolyte.
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References
Geiduschek, K., and Holtzer, A., Adv. in Biol. and Med. Phys., 6, 431 (Academic Press, 1958).
Coates, J., and Jordan, D., Biochim. Biophys. Acta, 43, 214 (1960).
Fresco, J., Trans. N.Y. Acad. Sci., 21, 658 (1959).
Fresco, J., and Klemperer, E., Ann. N.Y. Acad. Sci., 81, 730 (1960).
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STEINER, R. Properties of Polyadenylic Acid in Methanol Solution. Nature 190, 340–341 (1961). https://doi.org/10.1038/190340b0
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DOI: https://doi.org/10.1038/190340b0
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