Abstract
THE opinion has been advanced that acetylcholine acts in the heart not only as the mediator of the vagus nerve but also as the so-called local hormone in local extraneural regulation of heart activity and that in this last function it is closely associated with heart automation1. If this view is correct, it can be assumed that the most rapid turnover of acetylcholine will occur in those parts of the heart which possess the highest degree of automation. In order to verify the correctness of this assumption, experiments were carried out in which the distribution of acetylcholine and cholinesterase in different parts of white rat heart was examined.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Burn, J. H., Physiol. Rev., 30, 177 (1950).
Rothschuh, K. E., Pflügers Arch., 258, 406 (1954).
Vlk, J., Arch. Exp. Path. Pharmakol., 235, 19 (1958).
Rothschuh, K. E., Pflügers Arch., 258, 481 (1954).
Mazel, P., and Holland, W. C., Circulation Res., 6, 684 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
VLK, J., TUČEK, S. & HABERMANN, V. Distribution of Acetylcholine and Cholinesterase in the Heart of White Rats. Nature 189, 923–924 (1961). https://doi.org/10.1038/189923b0
Issue Date:
DOI: https://doi.org/10.1038/189923b0
This article is cited by
-
Choline acetyltransferase in the heart of adult rats
Pflügers Archiv European Journal of Physiology (1982)
-
Inotropic responses to field stimulation in isolated atrial and ventricular muscle
Irish Journal of Medical Science (1980)
-
Heart tissue acetylcholine in chronically exercised rats
Experientia (1975)
-
Determination of cholinesterase activity in the myocardium at tissue pH by the method of potentiometric titration
Bulletin of Experimental Biology and Medicine (1966)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.