Abstract
Shanes and Bianchi1 have demonstrated that stimulation of frog sartorius muscle accelerates the release of calcium-45 loaded on muscles, although Harris2 had failed to observe this effect. Koketsu and Miyamoto3 recently confirmed an increase in the output of calcium-45 during muscle activity. An important problem remains, however, whether acceleration of calcium output during activity is caused by the mechanism specific of the contractile system or actually is responsible for the electrical membrane phenomena. Hodgkin and Keynes4 have reported that no change in calcium efflux can be detected during stimulation of squid axon, concluding that calcium movement during nervous activity is wholly inward. Furthermore, the 30-fold greater influx of calcium per impulse in muscle than in nerve despite the near equality of the resting influxes has been noted as consistent with a special role for calcium in contraction5.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Shanes, A. M., and Binachi, C. P., J. Gen. Physiol., 43, 481 (1960).
Harris, E. J., Biochem. Biophys. Acta, 23, 80 (1957).
Koketsu, K., and Miyamoto, S., see following communication.
Hodgkin, A. L., and Keynes, R. D., J. Physiol., 138, 353 (1957).
Bianchi, C. P., and Shanes, A. L., J. Gen. Physiol., 42, 803 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KOKETSU, K., MIYAMOTO, S. Release of Calcium-45 from Frog Nerves during Electrical Activity. Nature 189, 402–403 (1961). https://doi.org/10.1038/189402a0
Issue Date:
DOI: https://doi.org/10.1038/189402a0
This article is cited by
-
Action of Procaine on Calcium Efflux from Frog Nerve and Muscle
Nature (1968)
-
Release of Adenine Nucleotide from Nerve Axons
Nature (1964)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.