Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Increased Dihydrofolate Reductase Activity as a Possible Basis of Drug Resistance in Leukæmia

Nature volume 189, pages 39–42 (1961)Cite this article

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Law, L. W., Cancer Res., 16, 698 (1956).

    CAS  Google Scholar 

  2. Nichol, C. A., in Rebuck, J. W., Bethell, F. H., and Monto, R. W., eds., “The Leukemias”, 583 (Academic Press, New York, 1957).

    Google Scholar 

  3. Broquist, H. P., Kohler, A. R., Hutchison, D. J., and Burchenal, J. H., J. Biol. Chem., 202, 59 (1953).

    CAS  PubMed  Google Scholar 

  4. Nichol, C. A., Zakrzewski, S. F., and Welch, A. D., Proc. Soc. Exp. Biol. Med., 83, 272 (1953).

    Article  CAS  Google Scholar 

  5. Fischer, G. A., and Welch, A. D., Science, 126, 1018 (1957).

    Article  ADS  CAS  Google Scholar 

  6. Anton, A. H., and Nichol, C. A., Biochem. Pharm., 3, 1 (1959).

    Article  CAS  Google Scholar 

  7. Nichol, C. A., and Welch, A. D., Proc. Soc. Exp. Biol. Med., 74, 403 (1950).

    Article  CAS  Google Scholar 

  8. Osborn, M. J., Freeman, M., and Huennekens, F. M., Proc. Soc. Exp. Biol. Med., 97, 429 (1958).

    Article  CAS  Google Scholar 

  9. Werkheiser, W. C., Proc. Amer. Assoc. Cancer Res., 3, 161 (1960).

    Google Scholar 

  10. Zakrzewski, S. F., Fed. Proc., 19, 411 (1960).

    Google Scholar 

  11. Humphreys, S. R., and Goldin, A., J. Nat. Cancer Inst., 23, 633 (1959).

    CAS  PubMed  Google Scholar 

  12. Goldin, A., Humphreys, S. R., Chapman, G. O., Chirigos, M. A., and Venditti, J. M., Nature, 185, 219 (1960).

    Article  ADS  CAS  Google Scholar 

  13. Humphreys, S. R., Mead, J. A. R., Venditti, J. M., and Schrecker, A. W. (unpublished observations).

  14. Law, L. W., Taormina, V., and Boyle, P. J., Ann. New York Acad. Sci.(2), 60, 244 (1954).

  15. Osborn, M. J., and Huennekens, F. M., J. Biol. Chem., 233, 969 (1958).

    CAS  PubMed  Google Scholar 

  16. Futterman, S., J. Biol. Chem., 228, 1031 (1957).

    CAS  PubMed  Google Scholar 

  17. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol Chem., 193, 265 (1951).

    CAS  PubMed  Google Scholar 

  18. Nichol, C. A., and Welch, A. D., in Rhoads, C. P., ed., “Antimetabolites and Cancer” 63 (Amer. Assoc. Adv. Sci., 1955).

    Google Scholar 

  19. Aronow, L., J. Pharm. Exp. Therap., 127, 116 (1959).

    CAS  Google Scholar 

  20. Hakala, M. T., Zakrzewski, S. F., and Nichol, C. A., Proc. Amer. Assoc. Cancer Res., 3, 115 (1960).

    Google Scholar 

  21. Fischer, G. A., Proc. Amer. Assoc. Cancer Res., 3, 111 (1960).

    Google Scholar 

  22. Fountain, J. R., Hutchison, D. J., Waring, G. B., and Burchenal, J. H., Proc. Soc. Exp. Biol. Med., 83, 369 (1953).

    Article  CAS  Google Scholar 

  23. Werkheiser, W. C., Proc. Amer. Assoc. Cancer Res., 3, 72 (1959).

    Google Scholar 

  24. Charache, S., Condit, P. T., and Humphreys, S. R., Cancer, 13, 236 (1960).

    Article  CAS  Google Scholar 

  25. Goldin, A., Venditti, J. M., Humphreys, S. R., and Mantel, N., J. Nat. Cancer Inst., 21, 495 (1958).

    CAS  PubMed  Google Scholar 

  26. Goldin, A., Humphreys, S. R., Venditti, J. M., and Mantel, N., J. Nat. Cancer Inst., 22, 811 (1959).

    CAS  PubMed  Google Scholar 

  27. Brockman, R. W., Sparks, C., Simpson, M. S., and Skipper, H. E., Biochem. Pharm., 2, 77 (1959).

    Article  Google Scholar 

  28. Reichard, P., Skold, O., and Klein, G., Nature, 183, 939 (1959).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Tufts University School of Medicine, Boston, Massachusetts

    D. K. MISRA, STEWART R. HUMPHREYS,  MORRIS FRIEDKIN,  ABRAHAM GOLDIN & ELIZABETH J. CRAWFORD

  2. Laboratory of Chemical Pharmacology, National Cancer Institute, Bethesda, Maryland

    D. K. MISRA, STEWART R. HUMPHREYS,  MORRIS FRIEDKIN,  ABRAHAM GOLDIN & ELIZABETH J. CRAWFORD

Authors
  1. D. K. MISRA
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. STEWART R. HUMPHREYS
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. MORRIS FRIEDKIN
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. ABRAHAM GOLDIN
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. ELIZABETH J. CRAWFORD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

MISRA, D., HUMPHREYS, S., FRIEDKIN, M. et al. Increased Dihydrofolate Reductase Activity as a Possible Basis of Drug Resistance in Leukæmia. Nature 189, 39–42 (1961). https://doi.org/10.1038/189039a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/189039a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing