Abstract
THE sera of children with ulcerative colitis have been shown to contain a γ-globulin which reacts with an antigen prepared by phenol–water extraction of human colon. The serum factor may be termed an auto-antibody1. This communication presents evidence that antibody against the same antigen also occurs in the regional colonic lymph glands but not in the ileal glands of the patients and that it is bound to the microsomes of the colonic glands.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Broberger, O., and Perlmann, P., J. Exp. Med., 110, 657 (1959).
Kern, M., Helmreich, E., and Eisen, H. N., Proc. U.S. Nat. Acad. Sci., 45, 862 (1959).
Dittebrandt, M., Amer. J. Clin. Pathol., 18, 439 (1948).
Middlebrook, G., and Dubos, R., J. Exp. Med., 88, 521 (1948).
Feldman, M., Elson, D., and Globerson, A., Nature, 185, 317 (1960).
Sorkin, E., and Boyden, S. V., J. Immunol., 75, 22 (1955). Rhodes, J. M., Sorkin, E., and Boyden, S. V., Biochim. Biophys. Acta, 25, 405 (1957); and personal communication.
Askonas, B. A., in “Mechanisms of Antibody Formation”, 231 (Prague, 1960).
For references and discussion, see Siekevitz, P., Exp. Cell Res., Supp. 7, 90 (1959). Peters, jun., T., J. Histochem. Cytochem., 7, 224 (1959). Campbell, P., Greengard, O., and Kernot, B. A., Biochem. J., 74, 107 (1960).
Thiery, G. P., in Ciba Foundation Symp. Cellular Aspects of Immunity, edit. by Wolstenholme, G. E. W., and O'Connor, M., 59 (London, 1960). Bernhard, W., and Granboulan, N., ibid, 92.
Palade, G. E., and Siekevitz, P., J. Biophys. Biochem. Cytol., 2, 171 (1956).
Perlmann, P., Hultin, T., Morgan, W., and D'Amelio, V., Exp. cell Res., Supp. 7, 279 (1959).
Mitchison, N. A., Nature, 171, 267 (1953); J. Exp. Med., 102, 157 (1955). Billingham, R. E., Brent, L., and Medawar, P. B., Proc. Roy. Soc., B, 143, 58 (1954).
Snell, G. D., “Ann. Rev Microbiol.”, 11, 439 (1957). Medawar, P. B., in “Cellular and Humoral Aspects of the Hypersensitive State”, 504, edit. by Lawrence, H. Sh. (P. B. Hoeber, Inc., New York, 1959). Lawrence, H. Sh., Physiol. Rev., 39, 811 (1959).
Palade, G. E., J. Biophys. Biochem. Cytol., 1, 567 (1955); 2 (Supp.), 85 (1956).
Berrian, J. H., and Brent, L., Ann. N.Y. Acad. Sci., 73, 654 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PERLMANN, P., BROBERGER, O. Auto-Antibodies against Antigen derived from Colon in the Microsomes of Regional Colonie Lymph Glands in Human Ulcerative Colitis. Nature 188, 749–751 (1960). https://doi.org/10.1038/188749a0
Issue Date:
DOI: https://doi.org/10.1038/188749a0
This article is cited by
-
The Role of Prolonged Viral Gastrointestinal Infections in the Development of Immunodeficiency-Related Enteropathy
Clinical Reviews in Allergy & Immunology (2012)
-
Antibody to Tropomyosin Isoform 5 and Complement Induce the Lysis of Colonocytes in Ulcerative Colitis
American Journal of Gastroenterology (2009)
-
Association of ulcerative colitis and red blood cells coated with autoimmune antibody
The American Journal of Digestive Diseases (1963)
-
Immunologic “colitis” in dogs
The American Journal of Digestive Diseases (1962)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
