Vitamin A Acid and Hypervitaminosis A


ALTHOUGH vitamin A acid plays no part in the visual cycle1, it is active in the systemic functions of vitamin A in that it maintains normal growth and skin appearance1,2. With Prof. R. A. Morton, we have found (unpublished work) that vitamin A acid also prevents the rise of ubiquinone concentration in rat liver, a characteristic effect of vitamin A deficiency3.

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    Dowling, J. E., and Wald, G., Proc. Fourtn Int. Cong. Biochem., 11, 185 (1960).

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    Arens, J. F., and Van Dorp, D. A., Nature, 158, 60, 622 (1946).

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    Heaton, F. W., Lowe, J. S., and Morton, R. A., Biochem. J., 67, 208 (1957). Morton, R. A., and Phillips, W. E. J., Biochem. J., 73, 416 (1959).

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    Nieman, C., and Klein Obbink, H. J., Vitam. and Horm., 12, 69 (1954).

  5. 5

    Moore, T., in Symposium in Nutrition, edit. by Herriott, R. M., 55 (Johns Hopkins Press, Baltimore, 1953).

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THOMPSON, J., PITT, G. Vitamin A Acid and Hypervitaminosis A. Nature 188, 672–673 (1960).

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