Determination of Acid Phosphatase Activity in Cells of Prostatic Tumours


A SIMPLE technique by which cell material can be easily secured from prostatic tumours with the aid of transrectal aspiration biopsy has recently been described1. The material thus obtained was shown to consist largely of plugs of epithelial cells with occasional admixture of blood. In the present work these tissue fragments were isolated for determination of their acid phosphatase activity.

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  1. 1

    Franzén, S., Giertz, G., and Zajicek, J., Brit. J. Urol., 32, 193 (1960).

  2. 2

    Stolbach, L. L., Nisselbaum, J. S., and Fishman, W. H., Amer. J. Clin. Path., 29, 379 (1958).

  3. 3

    Tsuboi, K. K., and Hudson, P. B., Arch. Biochem. and Biophys., 55, 191 (1955).

  4. 4

    Rutenburg, A. M., and Seligman, A. M., J. Histochem. and Cytochem., 3, 455 (1955).

  5. 5

    Estborn, B. D., Nature, 184, 1636 (1959).

  6. 6

    Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).

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ESPOSTI, P., ESTBORN, B. & ZAJICEK, J. Determination of Acid Phosphatase Activity in Cells of Prostatic Tumours. Nature 188, 663–664 (1960).

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