Influence of Tranquillizing Drugs on Phagocytosis in vivo


PHAGOCYTOSIS of invading micro-organisms has long been known to play a major part in the defence of the mammalian organism against infectious disease. In view of the widespread use and potent pharmacological activity of the tranquillizing drugs, it is not surprising that administration of such compounds has occasionally been associated with alterations in normal resistance to infection1,2, and that such altered clinical responses have been linked to changes in the phagocytic activity of the reticulo-endothelial system3.


  1. 1

    Kline, N. S., Barsa, J., and Gosline, E., Dis. Ner. Syst., 17, 352 (1958).

    Google Scholar 

  2. 2

    Wardell, D. W., Amer. J. Psychiat., 185, 235 (1956).

    Google Scholar 

  3. 3

    Meier, R. M., Boroff, D. A., and Heller, J. H., Fed. Proc., 16, 425 (1957).

    Google Scholar 

  4. 4

    Vinegar, R., and Berger, F. M., Proc. Soc. Exp. Biol. Med., 102, 88 (1959).

    CAS  Article  Google Scholar 

  5. 5

    Ludány, G., Vajda, G., Döklen, A., and Li-Bok-Nam, Orvosi Hetilap, 96, 1100 (1955).

    PubMed  Google Scholar 

  6. 6

    Ludány, G., Vajda, G., Döklen, A., and Li-Bok-Nam, Schweiz. Med. Wochen., 86, 1075 (1956).

    Google Scholar 

  7. 7

    Kuna, A., Blattberg, B., and Reiman, J., Proc. Soc. Exp. Biol. Med., 77, 510 (1951).

    CAS  Article  Google Scholar 

  8. 8

    Dixon, Wilfred J., and Massey, jun., Frank J., “Introduction to Statistical Analysis”, second ed. (McGraw-Hill Book Co., Inc., New York, 1957).

    Google Scholar 

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GREENBERG, L., INGALLS, J. Influence of Tranquillizing Drugs on Phagocytosis in vivo . Nature 188, 588 (1960).

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