Presynaptic Nature of Neuromuscular Depression in the Frog


WHEN a number of successive nerve impulses arrive at a curarized neuromuscular junction, the induced end-plate potentials show a gradual decrease in size (Wedensky-inhibition, or junctional fatigue). Two different mechanisms, though not exclusive of each other, are conceivable.

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OTSUKA, M., ENDO, M. Presynaptic Nature of Neuromuscular Depression in the Frog. Nature 188, 501–502 (1960).

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