Letter | Published:

Cardiac Action and Pacemaker Potentials based on the Hodgkin-Huxley Equations

Nature volume 188, pages 495497 (05 November 1960) | Download Citation



SINCE the equations describing the nerve action potential were formulated by Hodgkin and Huxley1, the range of phenomena to which they have been shown to apply has been greatly extended. Huxley2has applied them to the influence of temperature on the propagated response and to the repetitive firing observed in low calcium concentrations. More recently, Fitzhugh3 has shown that the long action potentials induced by tetraethylammonium ions in squid nerve may also be reproduced.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    , and , J. Physiol., 117, 500 (1952).

  2. 2.

    , Ann. N.Y. Acad. Sci., 81, 221 (1959).

  3. 3.

    , J. Gen. Physiol., 43, 867 (1960).

  4. 4.

    , J. Physiol., 127, 213 (1955); “Elektrophysiologie der Herzmuskelfaser” (Hans Huber, Berne and Stuttgart, 1956).

  5. 5.

    , and (preceding communication).

  6. 6.

    , J. Physiol., Proceedings of the Physiological Society, September Meeting (1960).

Download references

Author information


  1. Department of Physiology, University College, London.

    • D. NOBLE


  1. Search for D. NOBLE in:

About this article

Publication history




Further reading Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.