Base Composition of Ribonucleic Acid from Rat Mammary Gland during Pregnancy and Late Lactation


RIBONUCLEIC acid has become increasingly associated with pathways of protein biosynthesis in many different types of tissue and there is a widely held belief that the sequential order of nucleotide bases in a particular ribonucleic acid molecule governs the amino-acid order of protein synthesized in its vicinity1. Incorporation of amino-acid, which has been equated with protein synthesis under certain conditions, has been shown to occur under these conditions in the intracellular fractions from many tissues. Differences in the ribonucleic acid base composition of mitochondrial, microsomal and supernatant fractions have been found for rat liver2,3.

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WANG, D., SLATER, T. & GREENBAUM, A. Base Composition of Ribonucleic Acid from Rat Mammary Gland during Pregnancy and Late Lactation. Nature 188, 320–321 (1960).

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