Abstract
IT is recognized1 that 2 : 4-dinitrophenol (DNP) stimulates the total oxidation of glucose by baker's yeast, which takes place mostly through the combined action of the Embden–Meyerhof and the citric acid cycles2. Nevertheless, the oxidation of pyruvate, a compulsory intermediate of glucose degradation in yeast, is strongly inhibited by DNP in the same experimental conditions that stimulate glucose oxidation3. In order to elucidate this apparent contradiction our previous experiments have been extended using substrates labelled with carbon-14.
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STOPPANI, A., RAMOS, E. & WIDUCZYNSKI, I. Different Action of 2 : 4-Dinitrophenol on the Oxidation of Exogenous and Endogenous Substrates by Baker's Yeast. Nature 188, 1188–1189 (1960). https://doi.org/10.1038/1881188a0
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DOI: https://doi.org/10.1038/1881188a0
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