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Serotonin, a Melanocyte-stimulating Component in the Dorsal Skin Secretion of Xenopus laevis


IT is well known that a variety of substances are able to produce a dispersion or concentration of the pigment granules in the melanocytes of Amphibia in vivo. However, the number of compounds which produce a dispersion or concentration of these granules in melanocytes of isolated pieces of skin is much smaller. Any secondary reactions may be excluded by this latter in vitro method of testing. At the present stage of investigation, in vitro studies may be of value, though it should be realized that what happens in Nature may not be comparable.

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