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Distribution of Protein-bound Aminoazo Dyes in the Rat Liver Microsome


EVIDENCE has been obtained that rat liver microsomes are the site where the formation of protein-bound aminoazo dyes occurs1‐3. On the other hand, one of the most important parts played by the microsome is known to be protein synthesis. Littlefield et al. 4 further fractionated the microsome by means of sodium deoxycholate and pointed out that the protein in the deoxycholate-insoluble fraction, ribonucleoprotein particles, showed a particularly high turn-over rate, suggesting that protein is in fact-synthesized in this fraction. This suggestion was supported by other authors5–7.

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    Hultin, T., Exp. Cell Res., 10, 71, 697 (1956); 13, 47 (1957).

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    Gelboin, H. W., Miller, J. A., and Miller, E. C., Cancer Res., 18, 618 (1958).

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    Arcos, J. C., and Arcos, M., Biochim. Biophys. Acta, 28, 9 (1958).

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    Littlefield, J. W., Keller, E. B., Gross, J., and Zamecnik, P. C., J. Biol. Chem., 217, 111 (1955).

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    Alfrey, V. G., Daly, M. M., and Mirsky, A. E., J. Gen. Physiol., 37, 157 (1953).

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    Hultin, T., Exp. Cell. Res., Supp., 3, 210 (1955).

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    Simkin, J. L., and Work, T. S., Biochem. J., 65, 307 (1957).

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    Schneider, W. C., and Hogeboom, G. H., J. Biol. Chem., 183, 123 (1950).

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    Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).

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    Terayama, H., Kusama, K., Teruya, K., Kuroda, S., and Nakayama, T., Gann, 49, 85 (1958).

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    Terayama, H., Kusama, K., and Aoki, T., Gann, 49, 97 (1958).

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