Letter | Published:

New Inhibitor of Monoamine Oxidase

Naturevolume 187pages941942 (1960) | Download Citation

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Abstract

THE following is the initial report of a structurally unique monoamine oxidase inhibitor, N-benzyl-N-methyl-2-propynylamine hydrochloride (A19120). This work includes in vitro action of this inhibitor on rat liver mitochondria as well as in vivo inhibition of monoamine oxidase of mouse brain and the liver.

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References

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    Hogeboom, G. H., Schneider, W. C., and Palade, G. E., J. Biol. Chem., 172, 619 (1948).

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    Conway, E. J., “Microdiffusion Analysis and Volumetric Error” (Macmillan Co., N.Y., 1958).

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    Udenfriend, S., Weissbach, H., and Clark, C. T., J. Biol. Chem., 215, 337 (1955).

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    Udenfriend, S., Witkop, B., Redfield, B. G., and Weissbach, H., Biochem. Pharmacol., 1, 160 (1958).

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Affiliations

  1. Abbott Laboratories, North Chicago, Illinois

    • J. D. TAYLOR
    • , A. A. WYKES
    • , Y. C. GLADISH
    •  & W. B. MARTIN

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https://doi.org/10.1038/187941a0

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