Proliferative Capacity of Acute Leukæmia Cells

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SEVERAL investigations have been carried out with the purpose of detecting some peculiarities in the deoxyribonucleic acid of leukæmic cells, particularly its content, its base composition and several of its physico-chemical characteristics. It can be expected that more valuable information might be obtained from the study of deoxyribonucleic acid metabolism than from the simple analysis of its static properties. The incorporation of several precursors of deoxyribonucleic acid in the total leucocyte pool has been investigated with chemical methods1–3. An increased uptake has been detected in leukæmic marrows as compared with normal ones1,2. However, such a study does not allow a direct comparison between normal and pathological marrows since with these techniques the importance of different leucocyte populations of various degree of maturation is necessarily overlooked. That holds particularly for acute leukæmia cells, of which the normal counterparts (that is, normal myeloblasts) represent only about 4 per cent of the whole cellular population in a normal bone marrow.

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GAVOSTO, F., MARAINI, G. & PILERI, A. Proliferative Capacity of Acute Leukæmia Cells. Nature 187, 611–612 (1960) doi:10.1038/187611a0

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