A Potent New Benzothiadiazine Diuretic

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Abstract

SINCE the discovery of chlorothiazide by Beyer et al. 1, a number of chemically related compounds have been shown to possess similar natriuretic and chloruretic actions2–4. Some of these agents, notably 3,4-dihydrochlorothiazide and its derivatives, differ from chlorothiazide primarily in a greater milligram potency, which may be associated with a longer duration of action5. These agents also inhibit carbonic anhydrase to a lesser extent than the unsaturated analogues, resulting in a lower urinary pH and generally a greater chloruretic response5,6.

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References

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    Beyer, K. H., Baer, J. E., Russo, H. F., and Haimbach, A. S., Fed. Proc., 16, 282 (1957).

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    Logemann, W., Giraldi, P. N., and Parenti, M. A., Nature, 182, 1510 (1958).

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    Renzi, A. A., Chart, J. J., and Gaunt, R., Toxicol. and App. Pharmacol., 1, 406 (1959).

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    Barrett, W. E., Rutledge, R. A., Sheppard, H., and Plummer, A. J., Toxicol. and App. Pharmacol., 1, 333 (1959).

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    Jones, J. H., and Jones, J. V., Brit. Med. J., ii, 928 (1959).

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    Taylor, R. M., and Winbury, M. M., Pharmacologist, 1 (2), 53 (1959).

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TAYLOR, R., WINBURY, M. A Potent New Benzothiadiazine Diuretic. Nature 187, 603–604 (1960) doi:10.1038/187603a0

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