Reversibility of an Inherited Metabolic Block (Inborn Error of Metabolism)

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Abstract

THE irreversibility and permanence of the basic defects in ‘inborn errors of metabolism’ have been regarded hitherto as essential pre-requisites of the condition as defined by Garrod1. The question is whether in the light of the following observations this aspect of Garrod's concept can yet be universally maintained.

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References

  1. 1

    Garrod, A. E., Lancet, ii, 142 (1908).

  2. 2

    Hutchison, J. H., and McGirr, E. M., J. Clin. Endocrinol. and Met., 14, 869 (1954).

  3. 3

    Zondek, H., Leszynsky, H. E., and Zondek, G. W., Acta Endocrinol., 29, 47 (1958).

  4. 4

    Zondek, H., Leszynsky, H. E., and Zondek, G. W., Brit. Med. J., i, 340 (1959).

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ZONDEK, H., LESZYNSKY, H. & STEIN, J. Reversibility of an Inherited Metabolic Block (Inborn Error of Metabolism). Nature 187, 515–516 (1960) doi:10.1038/187515a0

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