Letter | Published:

Localization of a Halogenated Porphyrin in Mouse Tumours

Naturevolume 187page1124 (1960) | Download Citation

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Abstract

SCHWARTZ et al. observed that certain commercially obtainable hæmatoporphyrin preparations were contaminated by a porphyrin capable of becoming localized in experimental tumours1,2, and that pure hæmatoporphyrin was unable to do so. These findings gave the impetus to the present work on halogenoporphyrins. The premise on the basis of which halogenoporphyrins were chosen was the assumption that the aforementioned impurity represents an intermediate formed in the course of the synthesis of hæmatoporphyrin from hæmin. One such intermediate could be bis-(2-bromo-ethyl)deuteroporphyrin. Since iodine–131 is a more convenient isotope for the purpose of labelling than isotopes of bromine, the iodine 131–labelled analogue was synthesized.

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References

  1. 1

    Schwartz, S., Absolon, K., and Vermund, H., Univ. Minn. Med. Bull., 27 (Oct. 15, 1955).

  2. 2

    “Progress thru Research”, 1956 (General Mills Inc., Minneapolis, Minn.).

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Affiliations

  1. Departments of Radiation Biology and Biochemistry University of Rochester School of Medicine and Dentistry, Rochester, New York

    • K. I. ALTMAN
    •  & K. SALOMON

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https://doi.org/10.1038/1871124a0

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