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Effect of Reserpine on the Nucleotide and Catecholamine Content of the Denervated Adrenal Medulla of the Rat

Naturevolume 187page1032 (1960) | Download Citation



RESERPINE causes a depletion of the catecholamines and adenosine triphosphate stored in the amine granules of the adrenal medulla1–3. This effect may, however, have been produced indirectly through the secretory nerves3. Such a stimulation of the medulla induced by insulin hypoglycæmia or morphine causes a concomitant release of amines and adenosine triphosphate4,5. The essential problem, however, is how reserpine causes amine depletion by direct action on the cells. As a preliminary attempt to elucidate this problem, the effect of reserpine on the nucleotide and amine content of the denervated rat medulla was studied.

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  1. 1

    Schümann, H. J., Arch. exp. Path. Pharmakol., 233, 237 (1958).

  2. 2

    Kirpekar, S. M., Goodlad, G. A. J., and Lewis, J. J., Biochem. Pharmacol., 1, 232 (1958).

  3. 3

    Hillarp, N.-Å., Acta physiol. scand. (in the press).

  4. 4

    Carlsson, A., and Hillarp, N.-Å., Acta physiol. scand., 37, 235 (1956).

  5. 5

    Carlsson, A., Hillarp, N.-Å., and Hökfelt, B., J. Biol. Chem., 227, 243 (1957).

  6. 6

    Hillarp, N.-Å., Jönsson, B., and Thieme, G., Acta physiol. scand., 47, 310 (1959).

  7. 7

    Hillarp, N.-Å., Acta anat., Suppl. 4 (1946).

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    Hillarp, N.-Å., Acta physiol. scand., 47, 271 (1959).

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  1. Department of Histology, University of Lund



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