Abstract
THE observation by Aiyar et al. 1 that thyrotoxicosis in the rat is accompanied by an increase in liver ubiquinone prompts us to record our own related findings. We have investigated the effect of thyroxine and 2,4-dinitrophenol on both ubiquinone and ubichromenol-levels in the rat, using animals from a stock colony and also from a vitamin-E deficient colony. Female rats were used, aged 3–4 months in one experiment and aged 15 months in another. The animals were divided into groups of six, and test groups received thyroxine, thyroxine and α-tocopheryl acetate, or 2,4-dinitrophenol. After three weeks on test, the rats were killed, and their hearts and livers (each organ pooled with others from the same group) were analysed for ubiquinone and ubichromenol by the method of Diplock et al. 2. The results are given in Table 1, the figures for ubiquinone and ubichromenol representing the total isoprenologue content3 in each case.
Similar content being viewed by others
Article PDF
References
Aiyar, A. S., Sulebele, G. A., Rege, D. V., and Sreenivasan, A., Nature, 184, 1867 (1959).
Diplock, A. T., Green, J., Edwin, E. E., and Bunyan, J., Biochem. J. (in the press).
Diplock, A. T., Edwin, E. E., Green, J., Bunyan, J., and Marcinkiewicz, S., Nature, 186, 554 (1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
EDWIN, E., GREEN, J., DIPLOCK, A. et al. Effect of Thyroxine and 2,4-Dinitrophenol on Levels of Ubiquinone and Ubichromenol in the Rat. Nature 186, 725 (1960). https://doi.org/10.1038/186725a0
Issue Date:
DOI: https://doi.org/10.1038/186725a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.