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Periosteal Osteoclasts, Skeletal Development and Ageing

Naturevolume 185pages405407 (1960) | Download Citation



As far back as 1873, Kölliker1 observed the existence of osteoclasts in the periosteum of normal bone. Lacroix2 also made several references to the presence of periosteal osteoclasts during development of the perichondral collar of long bones. Quantitative information, however, is not available concerning the size of the population of periosteal osteoclasts and the appearance, disappearance, and stability of the population during ageing. The importance of the presence of these cells at periosteal sites has been largely neglected. Environmental conditions which are found in the periosteum make for an excellent study of osteoclastic origin, function, fate and biochemical nature.

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  1. Division of Experimental Pathology, Medical Research Center, Brookhaven National Laboratory, Upton, New York

    • E. A. TONNA


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