Phenazine Di-N-Oxide as a Carcinostatic Agent

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Abstract

PHENAZINE di-N-oxide has been found to be a carcinostatic agent for the Ehrlich ascites tumour. More than 90 per cent of tumour-bearing animals treated with this compound intraperitoneally survived 30 days or more, and were then free of tumours as compared with an average 13-day survival of the untreated control group. A comparison of this agent with other drugs active against this tumour reveals that 6-mercaptopurine, administered intraperitoneally1, or N-methylformamide, given orally2, extended mean survival time by 25–100 per cent, but that all animals died with ascites tumour. Other phenazine compounds, like the dye janus green B 3 have been reported to have activity against a transplanted mouse tumour, but only at toxic levels.

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References

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FURST, A., KLAUSNER, C. & CUTTING, W. Phenazine Di-N-Oxide as a Carcinostatic Agent. Nature 184, 908–909 (1959) doi:10.1038/184908b0

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