Abstract
IN recent studies in vivo and in vitro, we have shown that the K vitamins (K1, K2, phthiocol, menadione and ‘Synkavit’) inhibit the synthesis of nicotinic acid at the stage 3-hydroxyanthranilic acid→quinolinic acid. We suggested that the mechanism of inhibition is competition between vitamin K and 3-hydroxyanthranilic acid, that is, the K vitamins exert antimetabolitic action on the substrate of the reaction catalysed by 3-hydroxyanthranilic acid oxidase. On the basis of this hypothesis, investigations were undertaken to determine if the inhibition of 3-hydroxyanthranilic acid oxidase produced in vivo by administration of menadione or ‘Synkavit’ could be reversed by subsequent administration of 3-hydroxyanthranilic acid. The results of these experiments demonstrated the capacity of 3-hydroxyanthranilic acid to overcome the inhibitory effect of vitamin K.
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References
Quagliariello, E., et al., Boll. Soc. It. Biol. Sperim., 32, 1169, 1573, 1575 (1956); 33 1211, (1957); Giorn. Bioch., 7, 28, 36 (1958); Helv. Pediatr. Acta, 13, 486 (1958); Comm. Fourth Int. Cong. I. Biochem., Vienna, 1958.
Richert, D. A., J. Biol. Chem., 154, 1 (1944).
Evans, E., Lancet, i, 1072 (1956).
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QUAGLIARIELLO, E., SACCONE, C., RINALDI, E. et al. An Antimetabolic Action of Vitamin K. Nature 184, 820–821 (1959). https://doi.org/10.1038/184820a0
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DOI: https://doi.org/10.1038/184820a0
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