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Inhibition of Skeletal Formation in the Chick Embryo following Administration of Tetracycline


IT has been shown that tetracyclines form complexes with metallic ions1,2, that they become incorporated into bones of young mice3, and also that they are retained in bones of several other species for a considerable period following administration4–5. We have recently demonstrated6 that tetracycline inhibits skeletal formation in the sand dollar (Echinarachnius parma) embryo. The above observations prompted us to extend our previous studies and test the effect of the administration of tetracycline on developing chick embryos with special reference to the formation of the skeleton.

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  1. 1

    Regna, P. P., Solomons, I. A., Murai, K., Timreck, A. E., Brunings, K. J., and Lazier, W. A., J. Amer. Chem. Soc., 73, 4211 (1951).

  2. 2

    Albert, A., Nature, 172, 201 (1953).

  3. 3

    Torsten, Andre, Acta Radiol., Supp. 142, 1 (1956).

  4. 4

    Milch, R. A., Rall, D. P., Tobie, J. E., J. Nat. Cancer Inst., 19, No. 1, 87 (1957).

  5. 5

    Milch, R. A., Rall, D. P., Tobie, J. E., J. Bone and Joint Surg., 40 A, No. 4, 897 (1958).

  6. 6

    Bevelander, G., Nakahara, H., Rolle, G. K., Int. Arch. for Oral Path., (in press).

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