Abstract
DEMONSTRATION of circulating thyroglobulin antibodies by the gel diffusion-precipitation technique is a simple procedure which can be used for routine laboratory diagnosis of Hashimoto's thyroiditis1. Witebsky and Rose2, Roitt and Doniach1 and Owen and Smart3 have also applied Boyden's tannic acid hæmagglutination technique for detection of thyroid antibodies and have demonstrated its greater sensitivity over the precipitation technique. The tannic acid hæmagglutination technique is however in our experience, less easy to adapt as a routine procedure because it is complex in its performance and requires minute attention to detail to produce consistent results. A recent report by Bozicevich et al. on the successful use of bentonite particles, coated with human γ-globulin, in the detection of the rheumatoid serum factor prompted us to try this substance sensitized with thyroid antigen in the detection of thyroid antibodies.
Similar content being viewed by others
Article PDF
References
Roitt, I. M., and Doniach, D., Lancet, ii, 1027 (1958).
Witebsky, E., and Rose, N. R., J. Immunol., 76, 408 (1956).
Owen, S. G., and Smart, G. A., Lancet, ii, 1034 (1958).
Bozicevich, J., Bunim, J. J., Freund, J., and Ward, S. B., Proc. Soc Exp. Biol. and Med., 97, 180 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
AGER, J., HUTT, M. & SMITH, G. Detection of Thyroid Antibodies using Bentonite Particles. Nature 184, 478 (1959). https://doi.org/10.1038/184478a0
Issue Date:
DOI: https://doi.org/10.1038/184478a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.