Letter | Published:

8-Azaguanine Inhibition of Hæmoglobin Synthesis in De-embryonated Chick Blastoderm


THAT an important relationship exists between nucleic acid metabolism and protein synthesis is well known. The addition of some analogues of nucleic acid components to developing systems has been shown to result in abnormal growth, differentiation or cell division, which it is assumed are due to an interference with normal protein synthesis. Investigations concerned with the effect of nucleic acid analogues on the formation of a specific protein have been restricted mostly to micro-organisms1,2.

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  1. 1

    Gale, E. F., “Enzymes, Units of Biological Structure and Function”, (Academic Press, New York, 1956).

  2. 2

    Spiegelman, S. ibid.

  3. 3

    New, D. A. T., J. Emb. Exp. Morphol., 3, 326 (1955).

  4. 4

    Hamburger, V., and Hamilton, H. L., J. Morph., 3, 326 (1955).

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