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Noradrenaline and Adrenaline in the Rat Brain during Acute and Chronic Morphine Administration and During Withdrawal

Nature volume 184, pages 1950–1951 (1959)Cite this article

Abstract

FOLLOWING the demonstration of a release of catecholamines by morphine from the brain stem of cats and dogs1, my interest became focused on the mechanism of this release and the possible role of brain catecholamines in the morphine abstinence syndrome. In many this syndrome is characterized by signs of autonomic activity, for example, tremor, piloerection, lachrymation, salivation, fever, excitement mydriasis2. The same symptoms can be induced experimentally by electrical stimulation of hypothalamic and limbic brain areas of various laboratory animals3 and chemically by interference with the brain-stem content of some biogenic amines4,5.

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References

  1. Vogt, M., J. Physiol., 123, 451 (1954).

    Article  CAS  Google Scholar 

  2. Kolb, L., and Himmersbach, C. K., Amer. J. Psychiat., 94, 759 (1938).

    Article  Google Scholar 

  3. Fulton, J. F., Quart. Bull. Northw. Unv. Med. School., 24, 10 (1954).

    Google Scholar 

  4. Zeller, E. A., and Barsky, J., Proc. Soc. Exp. Biol. and Med., 81, 459 (1952).

    Article  CAS  Google Scholar 

  5. Shore, P., and Brodie, B. B., Proc. Soc. Exp. Biol. and Med., 94, 433 (1957).

    Article  CAS  Google Scholar 

  6. Euler, U. S. von, and Orwén, I., Acta Physiol. Scand., 33 suppl. 118, 1 (1955).

  7. Euler, U. S. von, Arch. Internat. Pharmacodyn., 77, 477 (1948).

    Google Scholar 

  8. Hougs, W., and Thorshauge, Ch., Acta Pharmacol., 15, 275 (1959).

    Article  CAS  Google Scholar 

  9. Barlow, O. W., J. Lab. and Clin. Med., 18, 785 (1933).

    CAS  Google Scholar 

  10. Mayor, A., and Wiki, B., Arch. Internat. Pharmacodyn., 21, 477 (1911).

    Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Alcohol Research, Karolinska Institute, Stockholm, 6

    LARS-M. GUNNE

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  1. LARS-M. GUNNE
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GUNNE, LM. Noradrenaline and Adrenaline in the Rat Brain during Acute and Chronic Morphine Administration and During Withdrawal. Nature 184, 1950–1951 (1959). https://doi.org/10.1038/1841950a0

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