Abstract
HERBERT1 has reported that calcium is obligatory for absorption of vitamin B12 by liver slices in the presence of intrinsic factor, since the addition of a calcium binder—the di-sodium salt of ethylene diamine tetra acetate (EDTA) decreased the intrinsic factor effect. Minard and Wagner2 made similar observations with liver homogenates in which calcium increased vitamin B12 uptake in the presence of intrinsic factor.
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References
Herbert, V., J. Clin. Invest., 37, 646 (1958).
Minard, F. N., and Wagner, C. L., Proc. Soc. Exp. Biol. Med., 98, 684 (1958).
Abels, J., Woldring, M. G., Nieweg, H. O., Faber, J. G., and de Vries, J. A., Nature, 183, 1395 (1959).
Gräsbeck, R., and Nyberg, W., Scand. J. Clin. Lab. Invest., 10, 448 (1958).
Gräsbeck, R., Kantero, I., and Siurala, M., Lancet, i, 234 (1959).
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RICE, E., GREENBERG, S., HERNDON, J. et al. Effect of Ethylenediamine Tetra-acetate on Vitamin B12 Absorption in the Rat. Nature 184, 1948 (1959). https://doi.org/10.1038/1841948a0
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DOI: https://doi.org/10.1038/1841948a0
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