Abstract
FOR the past two years1, it has been clear that the development of a new and convenient method for the synthesis of the berberine alkaloids hinged on the preparation of 6,7-methylenedioxy (I)- and 6,7-dimethoxyisoquinoline aldehydes (II). The use of the first of these in the synthesis of tetrahydroberberine and related alkaloids has been reported2. The present communication describes the preparation and use of the dimethoxyisoquinoline aldehyde (II). 
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References
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BRADSHER, C., DUTTA, N. Berberine Alkaloids via 6,7-Dimethoxyisoquinoline-l-aldoxime. Nature 184, 1943–1944 (1959). https://doi.org/10.1038/1841943b0
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DOI: https://doi.org/10.1038/1841943b0
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