Abstract
THE distribution of zinc-65 in the tissues of rats, following intravenous injection of a ‘65Zn-serurn-protein complex’, has been studied by Gilbert and Taylor1 who showed that the zinc-65 rapidly became uniformly distributed throughout the zinc contained in the soft tissues. These authors concluded that the zinc in the soft tissues could be considered to exist in one large ‘soft tissue zinc pool’ freely exchanging with the zinc in the plasma. As a result of preliminary measurements in rats bearing subcutaneously implanted tumours it was suggested that the tumour could probably be considered to form part of the soft tissue pool. In this report the distribution of zinc-65 in the tissues of rats bearing a subcutaneous mammary tumour is described and it is shown that the zinc in the tumour can be considered to form part of the soft tissue zinc pool.
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References
Gilbert, I. G. F., and Taylor, D. M., Biochem. Biophys. Acta, 21, 551 (1956).
Bartholomew, M. E., Tupper, R., and Wormall, A., Biochem. J., 71, 15, P (1959).
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TAYLOR, D. Behaviour of Zinc and Radiozinc in Tumour-Bearing Rats. Nature 184, 1649–1650 (1959). https://doi.org/10.1038/1841649a0
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DOI: https://doi.org/10.1038/1841649a0
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