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Effects of 1,4 Dihydrazinophthalazine on Organ Content and Adrenal Medullary Secretion of Catechol Amines

Nature volume 184, pages 1646–1647 (1959)Cite this article

Abstract

IN view of possible casual relationships between the effect of reserpine on the catechol amines and its effect on the elevated arterial blood pressure in hypertension, it seemed relevant to us to study the effects on catechol amine metabolism of another type of anti-hypertensive drug, 1,4-dmydrazinophthalazine (‘Nepresoline’, Ciba). The hypotensive properties of the hydrazinophthalazines were first reported in 1950 by Gross, Druey and Meier1. Following intravenous injection of ‘Nepresoline’ the blood pressure fell. This started after 10–20 min. and lasted for several hours. The hydrazinophthalazines are known to have some sympatholytic activity2 and have been shown in vitro to inhibit DOPA-decarboxylase, thus possibly interfering with catechol amine synthesis3.

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References

  1. Gross, F., Druey, J., and Meier, R., Experentia, 6, 19 (1950).

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  2. Bein, H. J., Gross, F., and Tripod, J., Schweitz. Med. Wschr., 83, 14 (1953).

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Authors and Affiliations

  1. Karolinska Institutet, Stockholm

    M. BYGDEMAN & L. STJARNE

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  1. M. BYGDEMAN
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  2. L. STJARNE
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BYGDEMAN, M., STJARNE, L. Effects of 1,4 Dihydrazinophthalazine on Organ Content and Adrenal Medullary Secretion of Catechol Amines. Nature 184, 1646–1647 (1959). https://doi.org/10.1038/1841646a0

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