Abstract
IT was suggested in a previous communication1 that the fall in coenzyme A liver concentrations in animals treated with vanadium might be due, at least partially, to a reduction in the number of —SH groups available. This hypothesis was based on the following facts: (1) The toxic effects of vanadium may, to a great extent, be attributed to modifications in reactions connected with sulphur compounds, especially those of the thiolic type2. (2) The lack of —SH groups, and particularly of sulphurated amino-acids, lowers the coenzyme A content in the liver3; in this case, a fall in thioctic acid, the connexion of which with coenzyme A is well-known, also occurs in the tissues4.
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MASCITELLI-CORIANDOLI, E., CITTERIO, C. Intracellular Thioctic Acid and Coenzyme A following Vanadium Treatment. Nature 184, 1641 (1959). https://doi.org/10.1038/1841641a0
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DOI: https://doi.org/10.1038/1841641a0
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