Letter | Published:

Peptides with Oxytocic and Pressor Activity obtained from Acidified Rat Serum


INCUBATION at 38° produces an increase in oxytocic activity in the acidified serum of normal rats (Croxatto, H. B., and Croxatto, H., unpublished work). Earlier studies have revealed that pepsitensin-like substances can be obtained from hypertensinogen under similar conditions1. This communication describes experiments carried out to determine some of the properties of the substance (or substances) extracted from acidified and incubated rat serum.

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  1. 1

    Alonso, O., Croxatto, R., and Croxatto, H., Proc. Soc. Exp. Biol. Med., 52, 61 (1943).

  2. 2

    Rocha e Silva, N., ‘Polypeptides which stimulate Plain Muscle’, edit. by Gaddum, J. H. (E. & S. Livingstone, Ltd., Edinburgh, 1955).

  3. 3

    Hawker, R. W., and Robertson, P. A., Endocrin., 63, 242 (1958).

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